News News
Contact us
  • Customer service number:64321087
  • Commercial service telephone:13918059423
  • Technical service telephone:13918059423
  • Contact person: Mr. Cui 
  • Service email:shxtb@163.com
  • Address: room 107, building 8, no. 100, guilin road, xuhui district, Shanghai

Multifunctional YHM shows promise for diagnosis and treatment of orthotopic glioma

The date of: 2022-05-07
viewed: 3
source: News medical


Glioma is an intracranial malignant tumor that still poses a major clinical challenge due to its highly invasive nature, low cure rate, and high mortality rate. Although advanced molecular imaging techniques, such as magnetic resonance imaging (MRI) and computed tomography (CT) can be used for glioma diagnosis, their low spatial resolution, harmful ionization, and complicated workflow limit their application in real-time intraoperative imaging.
In a new paper published in Light Science & Application, a team of scientists, led by Professor Hongjie Zhang and Professor Yinghui Wang from State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences, China, Jianhua Liu from Department of Radiology, The Second Hospital of Jilin University, China, and co-workers have developed a core-shell structured nanotheranostic agent (YVO4:Nd3+-HMME@MnO2-LF, marked as YHM) with YVO4:Nd3+ particles as the core and MnO2 nanosheets as the shell. Sonosensitizer hematoporphyrinmonomethyl ether (HMME) and lactoferrin (LF) were further loaded and modified on the surface, giving it a good ability to cross the BBB, near-infrared fluorescence imaging in the second window (NIR-II)/MRI bimodality, and highly efficient sonodynamic therapy (SDT) of orthotopic gliomas. The YVO4:Nd3+ core exhibited good NIR-II fluorescence properties, enabling YHM to act as promising probes for NIR-II fluorescence imaging of vessels and orthotopic gliomas. The MnO2 shell can not only provide O2 in the tumor microenvironments (TME) to significantly improve the healing efficacy of SDT, but also release Mn2+ ions to achieve T1-weight MRI in situ. Non-invasive SDT can effectively restrain tumor growth. This work not only demonstrates that multifunctional YHM is promising for diagnosis and treatment of orthotopic glioma, but also provides insights into exploring the theranostic agents based on rare earth-doped yttrium vanadate nanoparticles.



Hot News / Related to recommend
  • 2025 - 04 - 02
    Click on the number of times: 0
    source:SMALL CAPSAlligator Energy (ASX: AGE) has identified multiple uranium anomalies and some rare earth potential in analysis of results from its 2024 exploration program in the Alligator Rivers ur...
  • 2025 - 04 - 01
    Click on the number of times: 0
    source:Hebrew University of JerusalemResearchers have discovered an unexpected superconducting transition in extremely thin films of niobium diselenide (NbSe2). Publishing in Nature Communications, th...
  • 2025 - 03 - 31
    Click on the number of times: 0
    source:resourceworldBrazilian Rare Earths Limited [ASX: BRE] reported results of exploration drilling at the Pelé Target 1 Project, located in Bahia, Brazil.The Pelé Project is hosted within...
  • 2025 - 03 - 28
    Click on the number of times: 0
    source:SMALL CAPSEquinox Resources (ASX: EQN) has recorded high-grade heavy minerals content at its Mata da Corda rare earths project in Brazil.Notably, the company’s initial metallurgical results hav...
  • Copyright ©Copyright 2018 2020 Shanghai rare earth association All Rights Reserved Shanghai ICP NO.2020034223
    the host:Shanghai Association of Rare Earth the guide:Shanghai Development and Application Office of Rare Earth the organizer:Shanghai rare earth industry promotion center
    犀牛云提供云计算服务